What's up?
What do you mean by 'what'?
Are you asking a specific question or just saying 'what'?
Could you please clarify what you're referring to?
I'm sorry, I didn't catch what you said.
Can you please rephrase your question?
Are you asking about something in particular?
Do you need any help with something specific?
Please provide more context so I can understand what you're asking.
Is there something specific you'd like to know or discuss?